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In partnership with OneSkin. Editor’s Note: We only select and work with partners that meet our quality standards, so you can rest assured we only endorse products we believe in.
I’d like to start by saying: I’m not against Botox. My friends and I talk about it often, and I’m at the age where it makes sense as a potential investment (I’ve been putting it off for as long as I can). The people in my life who get Botox like their results, and I live in LA, so there’s no taboo here.
But as I’ve researched more, I’ve realized why it’s such an investment: injectables only smooth what’s visible; they don’t address why your skin is aging in the first place.
That’s where OneSkin’s OS-01 FACE Topical Supplement caught my attention.
Introducing OS-01
Developed by a team of female scientists, OS-01 FACE Topical Supplement is powered by the first peptide scientifically proven to target a root cause of skin aging: senescent cells, or “zombie cells,” that build up over time and accelerate decline. By reducing these cells, OS-01 helps skin behave more like it did years ago (promoting more collagen, holding onto hydration, and maintaining elasticity).
It has over 4,500 five-star reviews, is backed by impressive clinical data, and – I’ll repeat – was founded by a team of female scientists. Before I deep dove into the decades-long commitment of Botox, OS-01 FACE felt like the smartest stop along the way.
The Proof Is in the Data
OneSkin’s formula is different from just about any moisturizer I’ve tried. Alongside the OS-01 peptide, it’s loaded with supportive ingredients like niacinamide, hyaluronic acid, and synergistic peptides that strengthen the skin barrier, improve hydration, and soothe skin. And, the clinical results speak for themselves:
- 100% of participants had improved smoothness
- 95.5% had improved firmness, radiance, and tone
- 90% had improved elasticity
- 86% had improved appearance of fine lines and wrinkles
Botox vs. OS-01
Back to the Botox thing: to be clear, this isn’t “Botox in a bottle.” Botox freezes muscle movement; OS-01 improves skin health at the cellular level. They’re different tools, and they can complement one another. But if you’re looking for a topical that actually tackles aging at the source? You’re going to like this product.
Why I’m Using It Daily
The texture is lightweight, absorbs quickly, and jives well with the rest of my routine (yes, even retinol). After a few weeks of morning and evening use, my skin feels less reactive, more hydrated, and – the best word I can think of – sturdier.
As someone who’s skeptical of “miracle creams,” this one has earned a permanent spot on my shelf. I love that it’s science-backed, was developed by a team of women who just get it, and how my skin looks and feels after consistent use. I feel confident saying: this is a really smart investment.
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