Is OneSkin Worth the Splurge? I Tested Their Science-led Skincare Formulas to Find Out

In partnership with OneSkin. Editor’s Note: We only select and work with partners that meet our quality standards, so you can rest assured we only endorse products we believe in.

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I used to think of skincare as a sprint — the faster I could chase down results, the better. A dab of this, a slather of that, a haphazardly applied layer of SPF, and surely I’d be five years younger by Friday. But somewhere between entering my late 30s and realizing my skin had opinions of its own (sensitive ones, no less), I stopped chasing every shiny new cream that caught my eye. 

In a life lesson that goes far beyond skincare, I realized that quick fixes weren’t cutting it anymore. I needed consistency, reliability, and a refreshing dose of reality. At this point in my career, I know better than to expect a topical product to serve up the kind of transformation I’d get from lasers, microneedling, or a very skilled derm with a syringe. If that’s what I wanted, I know where to book an appointment. What I’m looking for is different, and thankfully, so is OneSkin. I had the opportunity to try two of the brand’s best-selling OS-01 products – here are my thoughts…

The No-Fuss Facial Moisturizer

Oneskin

OS-01 FACE Topical Supplement

$120
$120
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Credit: Oneskin

First up: their daily driver, the OS-01 FACE Topical Supplement moisturizer. I was immediately impressed by the packaging. It’s a reusable component (yay sustainability!) that opens to swap in refills when you finish. The airless pump is a big win in my book, so I’m not sticking my fingers into a glass jar or fiddling with a tiny spoon that I’ll inevitably lose. It’s thoughtful, no-frills, and clearly designed for ease over aesthetics — because we should be paying for what’s in the bottle, not outside of it. 

The peptide-powered formula is lightweight, absorbs quickly, and plays nicely with the rest of my routine (including retinols). After using the moisturizer morning and evening for about two weeks, I noticed that my skin felt less reactive — despite allergy season getting the best of me. I hadn’t needed to bust out the zit stickers and I didn’t wake up with dry patches, leading me to trust their scientific claims of the peptide increasing epidermal thickness and hyaluronic acid production. It’s like my skin found its groove again, and I was here for it.

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Because Body Care is Skincare

Oneskin

OS-01 BODY Topical Supplement

$99
$99
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Credit: Oneskin

Full transparency, I’ve been lazy about body care. Sure, I occasionally overachieve with exfoliation and indulgent body butters over every inch — but usually, I’m slapping on some lotion and calling it a day. 

So if you’re anything like me, here is the wake-up call you’ll need: the majority of our skin resides below our neck (97 percent, to be specific) and its inflammation can play a significant role in overall aging. Yep, aging does not stop at the neck — and OneSkin’s OS-01 BODY Topical Supplement aims to make sure we take equal care of our bodies. 

The formula itself is richer than the face version but absorbs lightning fast like a serum. No greasy residue or that cringey feeling that comes with putting leggings on over sticky moisturized legs (if you know, you know). Key ingredients like ceramides, niacinamide, and OneSkin’s patented OS-01 peptide work together to target those senescent cells that cause skin to lose bounce and elasticity. 

Fueled by years of neglect (and a little guilt), I committed to applying OS-01 BODY every single day. After a few weeks, my skin felt noticeably firmer and more hydrated — though I’ll admit, some of that glow may have come from simply showing up consistently. OneSkin notes that 12 weeks of daily use is where the real transformation kicks in, and based on the before-and-afters I’ve seen, I’m planning to stick with it.

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The No-Fuss Facial Moisturizer
Because Body Care is Skincare

Every Product is Named After Their Breakthrough — Here’s Why

Not only did I love how the products made my skin feel, but I was equally impressed by the brand behind them. OneSkin was founded by a team of female scientists focused on skin longevity, aiming to improve skin health at the cellular level without fear-mongering about aging (so much yes).

After five years of research and over 900 peptides tested, they developed OS-01: a patented peptide so core to their mission, every product is named after it. Scientifically proven to reduce skin’s biological age, OS-01 targets senescent “zombie” cells that speed up aging. Backed by rigorous trials and a growing base of loyal users, OneSkin is truly setting a new standard for what science-first, long-term skincare can be.

The Final Verdict

OneSkin isn’t going to make you look 10 years younger by next week, and that’s exactly what I like about them. They bring real science, smart formulas, and results that actually make your skin feel like it’s functioning better, not just looking temporarily dewy. After two weeks, my skin felt stronger and noticeably less reactive — not a dramatic transformation, but the kind of shift that made me want to keep going. And yes, it’s a splurge. But it’s a science-backed, clinically-tested, sustainably-packaged splurge that’s working with your skin, not against time. If you’re tired of throwing money at pretty jars that overpromise and underdeliver, this one’s worth it.

Try it for yourself here – and thank me later.

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